The expression of OPN, integrin αvβ3, and VCAM-1 was significantly higher in aorta tissues from the SCH group than in those from the CON group, and the expression of OPN, integrin αvβ3, and VCAM-1 in aorta tissues was also significantly higher in the CH group. The gene discussed is VCAM1; the disease is spindle cell hemangioma.