Furthermore, the other two Rdx family members, Selh and Selt, display a similar pattern of mRNA expression as that of Sepw1. While SelH has been implicated in maintaining genomic stability and redox regulation [41] and SelT is identified as a target of the pituitary adenylate cyclase-activating polypeptide regulating Ca2+ levels [42], exact roles of these two selenoproteins in PD brain await further investigation. Here, SELENOS is linked to Parkinson disease.