In order to explore the mechanism of DSG and 5-MOP on improving insulin resistance, we examined the protein expression on the PI3K/Akt pathway including p-Src (Tyr-416)/Src, PI3Kp85/β-actin, p-Akt (Ser473)/Akt, and p-GSK-3β (Ser9)/GSK-3β. This evidence concerns the gene AKT1 and Insulin resistance.