Although a strict relationship between obesity and cardiovascular and/or metabolic diseases exists (Jonk et al., 2007; Kobayasi et al., 2010; Campia et al., 2012), our obese mice showed no significant differences in systolic blood pressure, heart rate, glucose tolerance, and insulin sensitivity, albeit the insulin level was higher in the SD group. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.