INS and hydrops fetalis: Specifically, HF-ApoE4 (n = 10) mice have lower levels of peripheral plasma insulin after a 24 h starvation period (t(15) = 4.643, ***P = 0.0003), and higher glucose levels (t(15) = 2.924, *P = 0.0105) compared with HF-ApoE3 (n = 8) controls (Figure 3D).