Work by others suggests that the increase in BACE1 levels may be related to the HF consumption and the DM-like metabolic features (Patil et al., 2006; Zhang et al., 2009; Son et al., 2012), however, it has never been shown, to the best of our knowledge, in the ApoE4 AD model. This evidence concerns the gene BACE1 and hydrops fetalis.