In our work, we strengthen the above by showing that ApoE4 mice indeed gain less weight over time and display abnormal peripheral glucose/insulin levels, suggesting that the ε4 allele together with an imbalanced HF diet is sufficient to induce DM-like features, which in turn may also render ApoE4 carriers more susceptible to dementia and AD (Peila et al., 2002; Yang and Song, 2013). The gene discussed is APOE; the disease is Alzheimer disease.