Over the past few years, several reports have shown a correlation between high pathological PRL-3 expression and tumor progression of epithelial cancers (reviewed in Al-Aidaroos and Zeng, 2010; Guzińska-Ustymowicz and Pryczynicz, 2011; Rios et al., 2013), but the effect of aberrant PRL-3 expression on cellular polarity has not yet been examined. Here, PTP4A3 is linked to neoplasm.