SOD1 and colitis: This is in accordance with a previous study showing that docosahexaenoic acid downregulates SOD1 gene transcription through an HRE-mediated mechanism (HRE, hypoxia-response element), involving HIF signalling in human cancer cells [65]; thus our results indicate similar mechanism involved in SOD1 control in the murine colon mucosa in vivo during colitis and HBO2.