2001; Moeller et al. 2005), as well as, accelerates the metabolism of glucose, which reduces the intracellular glucose concentration and generates a gradient that favors the entry of glucose into the cells, and increases the expression of glucose transporters on the skeletal muscle and adipose tissue (GLUT4) (Potenza et al. 2009). Moreover, TH also increases the glycogenolysis and gluconeogenesis, which leads to glucose intolerance in hyperthyroid states (Goglia et al. 1999; Dimitriadis and Raptis 2001). This evidence concerns the gene SLC2A4 and Glucose intolerance.