2008; Nishimura et al. 2009). It is possible that this slight improvement in metabolic phenotype is due to changes in perinodal AT inflammation and reduced homing of dendritic cells to lymph nodes as was recently reported by Hellmann et al. (2016) and discussed in more detail below. Another possibility is that the CCR7−/− mice have reduced insulin secretion due to changes in their pancreas. For example, in a model of type 1 diabetes, desensitization to CCR7 blocked T‐cell migration into islets (Shan et al. 2014). Here, INS is linked to type 1 diabetes mellitus.