As for toxicity, one meta-analysis showed that the incidence of diarrhea and rash was higher in targeted therapy [10]; another found that grade 3 or 4 thrombocytopenia, diarrhea, and hypertension was significantly higher in anti-VEGF therapy compared to non-anti-VEFG therapy [22]. The gene discussed is VEGFA; the disease is Thrombocytopenia.