WWOX and colorectal cancer: In lung cancer, exonic polymorphisms within WWOX were revealed to exhibit a high incidence of the deletion of exon 6-8, which may result from amino acid changes and thus the loss of the tumor suppression function of WWOX. Furthermore, missense polymorphisms of WWOX, including Arg−314→His, Lys−182→Glu, Arg−120→Trp, and Thr−111→Ser, were detected in blood specimens from 15 and 34 patients with ovarian and colorectal cancers, respectively, but not in healthy participants [25].