Analysis of 104 BRAF mutant tumors in the melanoma TCGA data set showed that PTEN and Notch1 protein levels were inversely correlated (Spearman's r = −0.2871, p = 0.0031), whereas there was no significant correlation in NRAS mutant melanomas (n = 56, Spearman's r = −0.0832, p = 0.54), or tumors lacking BRAF or NRAS mutations (n = 48, Spearman's r = −0.1527; p = 0.3) (Figure 4C and Suppl. The gene discussed is NOTCH1; the disease is melanoma.