GPC3 was expressed in 78% (14 of 18) of well-differentiated tumors, 83% (24 of 29) of moderately-differentiated tumors, and 100% (9 of 9) of poorly differentiated tumors, while the size of the HCC was not related to the level of GPC3 expression. Here, GPC3 is linked to hepatocellular carcinoma.