We also found that the combination of ginsenoside Rg3 and EGFR-TKI was associated with a higher ORR in group A than in group B. These results indicate that ginsenoside Rg3 synergizes with EGFR-TKI treatment, and clinicians may consider the use of EGFR-TKI plus ginsenoside Rg3 to treat advanced NSCLC patients harboring EGFR active mutation. Here, EGFR is linked to non-small cell lung carcinoma.