EGFR and non-small cell lung carcinoma: In conclusion, our study provides the first evidence that the addition of ginsenoside Rg3 to EGFR-TKI confers a reduced susceptibility to drug resistance in treating NSCLC patients with EGFR active mutation, and that ginsenoside Rg3 can be a considerable agent to improve patient median PFS and delay acquired resistance to EGFR-TKI.