SMYD2 and B-cell chronic lymphocytic leukemia: Recent studies showed that Smyd2 over-expression may be critical in different tumor types, including HPV-unrelated head-and-neck carcinoma [22], pancreatic ductal adenocarcinoma (PDAC) [23], as well as CLL, where together with SMYD3 it may be associated with the acquisition of complex karyotypic alterations [24].