Accordingly, GO biological processes and KEGG pathways in the polyploidy-induced network are related to cancer, metabolism, cell cycle, stem cell pathways (Pi3K, Hippo, Hedgehog, WNT), EMT and MET pathways and stress response (Figure 4A), while again, the pathways of apoptosis, cell death, inflammation and cytoskeleton with Rho signaling elements are inhibited (Figure 4B). This evidence concerns the gene RHO and cancer.