Rho family GTPases were responsible for increased cell motility in PTP4A1 overexpressed colorectal cancer [16] and c-Src expression played an important role in PTP4A1 regulated lung cancer [17], whereas PTP4A1-mediated E-cadherin expression through PI3K/AKT signaling pathway was crucial to HCC motility [19]. The gene discussed is PTP4A1; the disease is hepatocellular carcinoma.