Tumor volume of HCCC9810-PTP4A1-derived and RBE-shCtl-derived xenografts was 132.34 ± 51.32 mm3 and 645.34 ± 223.43 mm3, respectively, significantly larger than that derived from HCCC9810-Ctl and RBE-shPTP4A1-1 groups (35.15 ± 20.85 mm3 and 195.26 ± 154.45 mm3, respectively, P<0.001). This evidence concerns the gene PTP4A1 and neoplasm.