To ask whether classical histone deacetylases (HDAC1-11) are also involved in deacetylation of AcAPE1, we treated colon adenocarcinoma HCT116 cells with trichostatin A (TSA), a specific inhibitor for classical HDACs [38], and measured AcAPE1 level. Here, HDAC1 is linked to colon adenocarcinoma.