This was evidenced by direct measurement of GSH (Figure 3C) and by the ability of NAC, a glutathione precursor and antioxidant, to prevent PEITC-induced ROS accumulation and suppress the drug-induced cell death both in primary 17p- leukemia cells from CLL patients (Figure 4) and in mouse leukemic cells from TCL1-Tg:p53−/− mice (Figure 5). The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.