Hence, based on our previous finding and emerging experimental evidence on the role of LOXL2 as a modulator of the metastatic niche [14, 15, 24], we hypothesized that LOXL2 expression in DTC will facilitate their emergence from tumor dormancy to metastatic growth by inducing cellular changes such as EMT and acquiring stem-like properties. Here, LOXL2 is linked to neoplasm.