Here we demonstrate that LOXL2, beyond its extracellular function as inducer of desmoplastic stroma [14, 20] and its intracellular function as an inducer of EMT and cancer cell invasion [18, 21, 26], can also endow DTC with CSC–like properties thus mediating their emergence from dormancy to proliferative growth. The gene discussed is LOXL2; the disease is cancer.