To further verify the effects of promoting the proliferation of GC cells of miR-424-5p over-expression were meditated by inhibiting the expression of Smad3, we have inhibited the expression of Smad3 alone to examine the effects of Smad3 on GC cell proliferation in SGC7901 cells by using shRNA (Figure 6a). The gene discussed is SMAD3; the disease is gastric cancer.