In addition to different roles in different stages of tumorigenesis, autophagy may have different functions in the context of different tumor mutational status; for example, although loss of autophagy delays tumorigenesis in Kras-driven pancreatic tumors, it accelerates tumorigenesis in Kras-driven pancreatic tumors with concurrent p53 mutation [22]. Here, TP53 is linked to pancreatic neoplasm.