In this regard, it is interesting to note that the PI3-Kinase mTOR pathway, which acts to inhibit the autophagy pathway [62, 63], has very recently been shown to contribute to the pathogenesis of both MPNSTs and neuroendocrine tumors, the two most common tumor types manifested by Tg(mitfa:atg5K130R);tp53M214K/+ fish [64, 65]. The gene discussed is MTOR; the disease is neuroendocrine neoplasm.