In CRC, similarly, univariate analysis showed that low IDH1-R132H expression (HR, 0.155, P<0.001) was correlated with poor OS, along with prognostic factors mentioned previously including differentiation (HR, 3.794, P<0.001), tumor stage (HR, 2.676, P<0.001), tumor size (HR, 9.889, P<0.001), lymph node metastasis (HR, 1.613, P<0.001), distant metastasis (HR, 8.031, P<0.001), and preoperative CEA level (HR, 2.230, P=0.011). The gene discussed is IDH1; the disease is metastatic malignant neoplasm in the lymph nodes.