ABL1 and Miyoshi myopathy: Although small-molecule kinase inhibitors have had a major impact on the treatment of several cancer types, including hematologic malignancies such as chronic myelogenous leukemia (ABL kinase inhibitors imatinib, dasatinib, and nilotinib) and mantle cell lymphoma (Bruton's tyrosine kinase inhibitor ibrutinib) [16], to date, no kinase inhibitors have been approved for use in MM.