CXCR4 and myocardial infarction: [68Ga]pentixafor, formerly termed [68Ga]CPCR4.2 (Fig. 1), represents a milestone in the development of CXCR4-targeted positron emission tomography (PET) probes [5, 6], since its pharmacokinetic properties and favorable dosimetry [7] led to a fast transition into first clinical studies, including in vivo quantification of CXCR4 expression in various types of cancers [8–13] and after myocardial infarction [14–16].