In the case of TLE1-mediated E-cadherin repression in NSCLC cells, Zeb1, an EMT promoting factor uniquely correlated with the loss of E-cadherin expression in human lung cancer cell lines [17], may, in part, underlie TLE1 recruitment to the E-cadherin promoter (Fig 8). This evidence concerns the gene ZEB1 and non-small cell lung carcinoma.