Recently, we showed that the Bit1 pathway is functionally suppressed in Non-Small Cell Lung Carcinoma (NSCLC) as evidenced by the selective downregulation of Bit1 expression and upregulation of the Bit1 inhibitor TLE1 in advanced human lung tumors as compared to normal human lung tissues [9]. The gene discussed is TLE1; the disease is non-small cell lung carcinoma.