A potential explanation is that patients weighing over 100 kg may be underdosed, as the maximum recommended dose of tPA is 0.9 mg/kg (Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008).19 Indeed, worse outcome at 3 months in tPA-treated patients has been reported in patients who were >100 kg compared with patients who were <100 kg.20,21. The gene discussed is PLAT; the disease is ischemic stroke.