ANXA1 and diabetes mellitus: Intriguingly, ANXA1 has been both positively and negatively associated with MMPs expression in cancer [178–180], and has been shown to be the target of AGE-dependent non-enzymatic glycosylation in pulmonary endothelial cells in STZ-induced T1DM [181], suggestive of a link between AGE and BBB breakdown in DM.