This is sometimes employed in analysis of large panels of cell lines; however, in any analysis of these or any data obtained from a diverse set of cancers, tissue of origin (or cancer type) will often be highly confounded (and sometimes perfectly confounded) with certain mutations; extreme examples include BCR-ABL1 in CML and EWS-FLI1 in Ewing’s sarcoma, where almost all samples will harbor these aberrations (and other cancer types will not). Here, EWSR1 is linked to Ewing sarcoma.