Our recent studies demonstrated that glaucomatous damage increases Bax gene and protein expression in the retina, as well as renders fission-mediated mitochondrial loss by altering OPA1 or DRP1 gene and protein expression in RGC axons of the glial lamina in a mouse model of glaucoma, DBA/2J mice18, 19, 37. This evidence concerns the gene OPA1 and glaucoma.