TRPV4 and irritable bowel syndrome: Further, we examined the effect of tegaserod, a clinically effective treatment of pain in IBS, and transient receptor potential channel, vanilloid 4 (TRPV4) antagonism, a high value target for the development of novel visceral analgesics in IBS.23–25 Finally, we sought to develop a chemosensitivity paradigm in which the efficacy of other novel analgesics could be tested against noxious inflammatory mediators.