Figure 1B shows that β1-integrin expression was significantly upregulated in the cells stably expressing COX-2 (compared with the control cells). By contrast, COX-2 siRNA decreased β1-integrin expression (Fig. 1C). Exogenous PGE2 treatment significantly increased β1-integrin expression in the three NSCLC cell lines (Fig. 1D). Here, PTGS2 is linked to non-small cell lung carcinoma.