Investigations using human induced pluripotent stem cell (iPSC)-derived RPE (iPSC-RPE) from patients with bestrophinopathies suggest that BEST1 influences fluid flux in cells; this may reflect a role for BEST1 as a vital component of the VRAC16 or through regulation of ER calcium stores24. Here, BEST1 is linked to autosomal recessive bestrophinopathy.