Regarding the small size effects of Angiotensin III, LH-RH 4–10 peptide fragment and 7H on phenotypes of R6/2 mice, we suspected the small effect could be due to too severe phenotypes of R6/2 mice and asked whether the effect might become more visible in the other HD model expressing full-length Htt at a physiological level. This evidence concerns the gene AGT and Huntington disease.