Finally, to validate the therapeutic effect on human neurons, the three candidate chemicals, Angiotensin III (#4028, RVYIHPF), 7H (HHHHHHH) and LH-RH 4–10 peptide fragment (L5387, SYGLRPG-NH2), were tested on human neurons derived from iPS cells of HD patients who had been established in the Coriell Institute (https://catalog.coriell.org). The gene discussed is AGT; the disease is Huntington disease.