DICER1 and retinal disorder: Apart from the OIR-resulted global changes of miRNA levels, we found that murine Alu-like B1/B2 elements were up-regulated in the OIR retinas associated with decreased Dicer1 (Fig. 4e), indicating a potential role of Dicer-deficiency-induced Alu element accumulation in retinal neovascularization and degeneration in proliferative retinopathy.