Accordingly, it would be insightful in future studies to assess time-dependent changes in AVP and AngII levels, and renal sorbitol and fructose levels, to look for correlations between peak changes in and/or chronic activation of these pathways with the promotion of hypertension (including any impact on circadian rhythm of arterial pressure) and aggravation of renal injury and dysfunction under conditions of recurrent dehydration. The gene discussed is AVP; the disease is hypertensive disorder.