ZDHHC21 and systemic inflammatory response syndrome: In Zdhhc21+/+ mice subjected to burn- or LPS-induced SIRS, the number of slow-rolling leucocytes, the fraction of slow-rolling leucocytes and leucocyte adhesion to the microvessel wall were significantly increased, and the average leucocyte rolling velocity was greatly reduced; however, Zdhhc21dep/dep mice were resistant to these responses (Fig. 7a,b).