We identified a protein that undergoes increased palmitoylation in endothelial cells upon SIRS stimulation, phospholipase C β1 (PLCβ1), an important signalling molecule downstream of the G-protein coupled receptors (GPCR) known to mediate the effects of inflammatory mediators such as thrombin and histamine. The gene discussed is PLCB1; the disease is systemic inflammatory response syndrome.