Consistent with the interpretation that TRPV4 channel blockade prevents cytokine elaboration instead of protecting target tissues from the deleterious effects of cytokines, we found that TRPV4 antagonism did not increase survival following induction of sepsis by injection of TNFα—a principal hyper-inflammatory cytokine produced in both LPS and CLP sepsis models. The gene discussed is TRPV4; the disease is Sepsis.