Administration of GSK219 blunted the LPS-induced increase in a large number of pro-inflammatory cytokines, including TNFα, IL-1α, and IL-6, cytokines suggested to be key mediators of the hyper-inflammatory response in sepsis (Fig. 2a–c), as well as eotaxin, GM-CSF (granulocyte/monocyte colony-stimulating factor), interferon (IFN)-γ, IL-1β, IL-3, IL-5, IL-12p40, IL-12p70, IL-13, IL-17α, MCP-1, MIP-1α, MIP-1β, RANTES (Suppl. The gene discussed is IL1B; the disease is Sepsis.