TNF and Sepsis: A recent study using cell therapy to target a broader range of sepsis mechanisms found that administration of fibroblastic reticular cells as much as 16 hours after LPS- or CLP-induced sepsis in mice decreased hyper-inflammatory cytokine levels and increased survival55, suggesting that targeting the hyper-inflammatory response as a whole may show more promising results than activated protein C and anti-TNFα antibody therapy in the treatment of sepsis13, 14, 15, 16.