PPIB and early-onset autosomal dominant Alzheimer disease: This suggests that the new family of cyclophilin inhibitors also has the potential for medical utility in a number of pathological conditions in which mPTP opening has been shown to be involved, such as protection against cardiac ischaemia-reperfusion injury, protection against hepatic ischaemia-reperfusion injury in the context of liver transplantation or neurocellular protection in the context of Alzheimer’s disease.