In the context of conditions such as inflammatory bowel disease, others have concluded that ‘dysregulated CD4 T cells responses to antigens of the microbiota leads to chronic, typically relapsing and remitting disease that reflects the immune system’s inability to eliminate the antigens that drive the abnormal response [20].’ This could apply to MS, also a predominantly relapsing-remitting disease. This evidence concerns the gene CD4 and inflammatory bowel disease.