A large number of studies show that ADGRL3 variants predispose to ADHD, modulate the pattern of brain metabolism, and predict ADHD severity (comorbidity with conduct disorder [CD], oppositional defiant disorder [ODD], and substance used disorder [SUD]) and response to stimulant medication (Arcos‐Burgos and Muenke 2010; Arcos‐Burgos et al. The gene discussed is ADGRL3; the disease is attention deficit-hyperactivity disorder.