+3001 T allele was observed only in T1D patients, whereas the +3010 CC genotype and the UTR-3 haplotype (14 bp del/+3001C/+3003T/+3010C/+3027C/+3035C/+3142G/+3187A/+3196C), associated with low and moderate soluble HLA-G expression, respectively, were underrepresented in patients. Here, HLA-G is linked to type 1 diabetes mellitus.