Moreover, consistent with the report that Ang 1–7 preserved cardiac function, coronary perfusion, and aortic endothelial function in a rat model of heart failure [230], Ang 1–7 improved cardiac recovery from ischemia/reperfusion and restored the normal reactivity to constrictor and dilator stimuli in the vasculature [231]. The gene discussed is ANGPT1; the disease is ischemia.