SETD7 and liver dysplastic nodule: To further understand the changes of HMT SET7/9 in p21 gene upregulation under diabetic conditions, we investigated the SET7/9 recruitment at p21 gene promoter in the glomeruli of STZ-induced diabetic rats and RMCs exposed to HG; the following results showed that SET7/9 occupancy was increased at p21 promoter in parallel with H3K4me1 increases both in vivo and in vitro, suggesting that SET7/9-dependent H3K4me1 plays key role in p21 gene expression leading to cellular hypertrophy associated with DN.