Several studies have demonstrated that both H3K4 HMT SET7/9 expression and SET7/9 recruitment at ECM associated genes promoters and p21 promoter were increased by TGF-β1 stimulation [25, 26], suggesting that SET7/9 is involved in TGF-β1-induced upregulations of genes associated with fibrosis and hypertrophy relevant to chronic kidney diseases including DN. This evidence concerns the gene TGFB1 and chronic kidney disease.