Some previous studies revealed that cancer cells produced the molecules that cause PTTM, which contains the tissue factor (Okubo et al. 2011), the vascular endothelial growth factor (Sakashita et al. 2007; Chinen et al. 2010; Takahashi et al. 2009; Yokomine et al. 2010) and osteopontin (Takahashi et al. 2009; Denhardt et al. 2001). The gene discussed is SPP1; the disease is cancer.