Beside Asp299Gly polymorphism within TLR4 gene, a study investigated the association between four new substitutions found by re-sequencing in the 5 V-proximal promoter region of the TLR4 gene and acute myocardial infarction, but they did not find the association (De Staercke et al. 2007). Here, TLR4 is linked to acute myocardial infarction.