Beside Asp299Gly polymorphism within TLR4 gene, a study investigated the association between four new substitutions found by re-sequencing in the 5 V-proximal promoter region of the TLR4 gene and acute myocardial infarction, but they did not find the association (De Staercke et al. 2007). The gene discussed is TLR4; the disease is myocardial infarction.