However, given that the mean inhibitory concentrations (IC50) of FPP and GGPP are very low at 1.18 μmol/L and 1.5 nmol/L, respectively, in MKD-like THP-1 cells (Table 1), a slight increase in FPP and GGPP levels induced by TAK-475 100 mg may give sufficient inhibition of IL-1β production in MKD patients and mitigate fever episodes. This evidence concerns the gene IL1B and mevalonic aciduria.