ADCY8 and neoplasm: Moreover, within-subject analysis of matched tumor and normal tissues verified differential promoter methylation for ADCY8, CDH8, and ZNF582. It is worth mentioning that when the current study was initiated, there were only 119 cases (year 2011 (N = 66), year 2012 (N = 53)) with 1 matched (tumor/normal) sample in TCGA.