We searched PubMed for publications on PCa and epigenetic therapy using the keywords: prostate cancer, DNA methylation, histone modifications, epigenetic drugs, DNMT inhibitors, HDAC inhibitors, histone modulators, HAT inhibitors, histone demethylase (HDM) inhibitors, and every drug mentioned on the manuscript, on January 15, 2016. The gene discussed is DNMT1; the disease is posterior cortical atrophy.