Recently, CUDC-101, which resulted from the incorporation of HDAC inhibitory functionality into the pharmacophore of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2)/NEU inhibitors [228], was able to reduce AR and AR-v7 expression, PCa cell proliferation in vitro and in vivo [229]. This evidence concerns the gene ERBB2 and posterior cortical atrophy.