Additionally, PCa cells exposed to hydralazine exhibited lower DNMT1, DNMT3a, and DNMT3b mRNA levels as well as lower DNMT1 protein, which may have contributed to the observed decrease in GSTP1, B cell CLL/lymphoma 2 (BCL2) and CCND2 promoter methylation levels, and concomitant gene re-expression. This evidence concerns the gene BCL2 and posterior cortical atrophy.