Recently, exposure of enzalutamide-resistant mCRPC cells to BETi (JQ1 and OTX015) resulted in attenuation of AR target genes (FKBP5, KLK3, ERG, and MYC) and AR-v7 expression as well as decreased CRPC cell proliferation in vitro and tumor growth in vivo. The gene discussed is MYC; the disease is neoplasm.