SPARC and posterior cortical atrophy: Exposure of PCa cells to curcumin decreased cell proliferation, increased apoptosis and downregulated several important metastasis-promoting genes, including cyclooxygenase-2 (COX2), Secreted Protein Acidic And Cysteine Rich (SPARC) and EGF-containing fibulin-like extracellular matrix protein (EFEMP) [236].