PTGS2 and posterior cortical atrophy: Several other genes were described as frequently hypermethylated in morphologically normal prostate tissue and in PIN (e.g., ATP binding cassette subfamily B member 1 (ABCB1), adenomatous polyposis coli (APC), cyclin D2 (CCND2), O-6-methylguanine-DNA methyltransferase (MGMT), retinoic acid receptor beta 2 (RARβ2), RASSF1A, prostaglandin-endoperoxide synthase 2 (PTGS2)) further implicating DNA hypermethylation in PCa initiation [37–39].