Importantly, another study demonstrated that sulforaphane effects are selective, since it more potently induced cell cycle arrest apoptosis and acetylation of H3 at P21 promoter and inhibited HDAC activity in benign hyperplasia (BPH1) and cancer (LNCaP and PC-3) PCa cells than in the normal cell line PrEC [209]. This evidence concerns the gene HDAC9 and posterior cortical atrophy.