CRTAP and infection: Interestingly, our study for the first time have identified gene signatures encompassing, PATJ and CRTAP (Cartilage Associated Protein) genes, which are well-known orchestrator of cell-cell contact and collagen assembly39, were found to be respectively down-regulated consistently in all DENV microarray data sets included in our meta-analysis study as well as during in-vitro infection of THP-1 cells with DENV (Figs 2 and 3d,e).