Having observed the functionality of these genes, it is tempting to speculate that down-regulation of the gene signatures comprising of PATJ and CRTAP might have an implication in DENV pathogenesis, possibly by altering virus penetration and permeability of target cells, which has been propounded to be a major factor in plasma leakage, a hallmark of Dengue Haemorrhagic fever. The gene discussed is PATJ; the disease is Dengue hemorrhagic fever.